St. Louis to Minneapolis - 10 Days

St. Louis to Minneapolis Cruise Summary

The wildness of the Upper Mississippi is a realm where storybook towns combine with sweeping panoramas and deep-blue lakes, conjuring the works of Mark Twain.

From the Gateway Arch of St. Louis to the birthplace of Prince in Minneapolis, this cruise will take you to some of America’s most vibrant, bustling metropolises, each one filled with culture and landmarks, music, food and history.

In Hannibal, explore the Mark Twain Caves, where the author spent his childhood – or immerse yourself in the vintage cars and memorabilia of 20th-century America, at the Karlocks Kars & Pop Culture Museum.

Tour the Isabel Bloom sculpture studio in Davenport, followed by Iowa’s oldest city – Dubuque. See the Driftless landscapes surrounding La Crosse and get up-close and personal with America’s iconic Symbol of Freedom at the National Eagle Centre of Wabasha, near the picturesque red-brick city of Red Wing.



  • Cruise through the stunning natural beauty of the Upper Mississippi region, the gateway to the American Midwest
  • Discover the Mark Twain Caves, said to have been used by Jesse James as a hideout
  • Tour the historic port city of Red Wing and go “nose to beak” with a bald eagle



2024 All-inclusive fares from £3,999 pp

st louis to minneapolis - minneapolis to st louis map

Order your FREE brochure

day-by-day itinerary


Day 1: St. Louis (Alton), Missouri

Arrive in St. Louis for your 2-night pre-cruise hotel stay.


Day 2: St. Louis (Alton), Missouri

Enjoy your time in St. Louis at your own leisure. Representatives from American Queen Voyages and our local port/city partner will be available to provide you with dining, entertainment and sightseeing options to maximise your time here.


Day 3: St. Louis (Alton)

During the Civil War, Alton was an important base for abolitionists, with Illinois as a free state across the river from the slave state of Missouri, and it served as the site of the final debate between Abraham Lincoln and Stephen Douglas in October of 1858. Among other noteworthy historical facts, Robert Wadlow, the world’s tallest man, was born and raised in Alton, as was the legendary jazz musician Miles Davis. Alton is also reputed to be one of the most haunted cities in the U.S.

Included Shore Excursions

St. Louis Full Day

Old Courthouse / Gateway Arch  Embrace this prime example of mid-19th century federal architecture. The Old Courthouse is known not only for its classic architecture, but also the notable cases presented in the courthouse, such as Dred Scott, who sued for his freedom from slavery. The Gateway Arch is symbolic of St. Louis. This iconic structure was completed in 1965 and has since provided millions of visitors with stunning views of up to 30 miles from east to west. Please note: Admission inside the Gateway Arch is additional.   Suggested Visit: 30 min – 2 hours

Cathedral Basilica of Saint Louis  Completed in 1914, this stunning cathedral was designed to meet the grandeur of European cathedrals. One of the most notable traits of the structure is its domed ceiling covered in mosaics portraying saints and milestones of the Catholic church in St. Louis. Enjoy the beauty and wonder of this structure dubbed by locals as the “New Cathedral.” Suggested Visit: 30 minutes



Day 4: Hannibal, Missouri

Located 100 miles north of St. Louis on the Mississippi River, Hannibal is one of Missouri’s and the region’s best tourism destinations. Hannibal could be described as ordinary, but the father of American literature would beg to differ. The town, with style and dignity, comes to life in the writings of Mark Twain. People, entities, and livelihoods of Hannibal’s past endure within the pages of “The Adventures of Huckleberry Finn” and “Life on the Mississippi,” and the town’s preservation efforts allow visitors to step right onto the page where Twain left off.

Included Shore Excursions

Hannibal Hop-On Hop-Off Tour
Big River Train Town This Hannibal gem is packed with more toy trains than you have probably ever seen. Enjoy authentic replicas as they move swiftly along the tracks or learn the history of the models and the trains they are made after. As you walk around, relive your childhood and learn the stories of the railways’ past as you view some authentic memorabilia.

Haunted House & Wax Museum This Wax museum features wax figures of Mark Twain and his characters which include real human hair and finger nails! There will be a guide there to tell you all the stories and talk about each one of the wax figures. Don’t forget to stop by the haunted house or the gift shop for some unusual finds!

Premium Shore Excursions

Step back in time to an era before television, before the internet and social media. A time of one of the most ground-breaking inventions of the early 1900s – The time of the radio. Join us as we explore the contemporary sounds of live radio theatre productions, which prompted families to gather around the radio and, for a moment, forget the worries of everyday life in the early 1900s. Today’s show features the local “Muddy River Radio” theatre group, an incredibly talented collection of entertainers known for their 1940s-style radio theatre productions. The group will take the stage and offer a nostalgic present for our guests with their rendition of America’s famous novel, “The Adventures of Huckleberry Finn.”


Day 5: Scenic River Cruising

Watch small river towns and lush landscapes slowly become lost in the horizon as sunlight plays upon the deck. Take hold of a literary classic, curl up on a plush chair in a cosy corner and relish in the moment of peace.



Day 6: Bettendorf, Iowa

Situated in southeastern Iowa, Bettendorf is part of a large metro area called the “Quad Cities,” a collection of river vistas and metropolitan communities that meld Midwestern neighbourliness with rich educational, cultural, and recreational opportunities. Comprised of the Mississippi riverfront towns of Bettendorf and Davenport in Iowa and Moline and Rock Island in Illinois, these distinctively different urban areas, without friction, blend into the melting pot that the region celebrates.

Included Shore Excursions

Bettendorf Hop-On Hop-Off Tour
Isabel Bloom Studio & Demonstration Isabel Rose Scherer was raised in the city of Davenport and began her artistic lifestyle early. In the early 1930s Isabel attended Grant Wood’s Stone City Art Colony where she learned how to carve limestone sculptures flawlessly. Her legacy lives on in the city of Davenport as her art pieces and influences are seen throughout the city, as well as her protégé, Donna Young, who works to help preserve Bloom’s legacy. During the 45-minute guided tour, enjoy behind-the-scenes access to every step in the making of each Isabel Bloom sculpture. Get a glimpse of some of her original art and photos and then visit the gift shop where you can purchase exclusive sculptures available only to tour guests. Suggested Visit: 45 minutes – 1 hour


Day 7: St. Dubuque, Iowa

Victorian meets bohemian in this ever-growing Mississippi River gem that’s sure to leave dazzling memories. In Dubuque you can check off your outdoor bucket list in the perfect nature getaway, and explore historic districts peppered with preserved history. Take a ride on the historic Fenelon Place Elevator, which is also the shortest, steepest, scenic railway, spanning 296 feet in length. Admire the 105 stained-glass Tiffany windows at St. Luke’s United Methodist Church, home to “one of the five finest religious Tiffany collections in the world.” See all the wildlife displays and hands-on exhibits at the National Mississippi River Museum. Cap your day in Dubuque with a tasting at one of the local vineyards or tasting rooms including Stone Cliff and Park Farm wineries.

Included Shore Excursions

Dubuque Hop-On Hop-Off Tour
Historic Millwork District This repurposed warehouse district is now home to niche retail stores, cafes, coffee shops, apartments, and offices. Offering authenticity and character, the Millwork District shows the importance of sustainable urban design strategies. At the start of the 20th century, the area was the innovative and entrepreneurial center of the region and was the backbone of the regional economy. Suggested Visit: 15 – 30 minutes

Dubuque Museum of Art Founded in 1874, the Dubuque Museum of Art (DuMA) is among Iowa’s oldest cultural institutions and a Smithsonian affiliate. The permanent collections and loans include more than 2,400 works reflecting the unique artistic and cultural heritage of our region, including one of the largest collections of works by internationally renowned Iowa artist Grant Wood. Suggested Visit: 30 minutes – 1 hour

Premium Shore Excursions
Is this Heaven? No, it’s Iowa. Immerse yourself in America’s Heartland on this journey through the scenes of the 1989 Academy Award winning film, Field of Dreams. Bubbling with baseball and Americana, this experience will lead you to the iconic locations in Dubuque, Iowa that made their debut on the big screen.

Day 8: La Crosse, Wisconsin

La Crosse resides along the famous Great River Road National Scenic Byway, considered by some as the most scenic drive in America. This river town also has a long-standing romance with the steamboat era, and as our paddlewheeler kisses its port, guests are welcomed by its eye-catching vistas and expansive waterfront park. The La Crosse Region is a proud part of the Driftless Region, a part of the world with an ancient, distinct topography and unparalleled views. “Drift” refers to glacial drift; the rock and sediment deposited by a glacier as it moves over an area of land. During the last Ice Age, a small piece of the Upper Mississippi Region was miraculously left untouched by glacial erosion and deposits. The surrounding landscapes that once featured prominent bluffs were levelled to plains and rolling hills, yet no glaciers entered one small pocket; thus, the Driftless Region became the last remnant of the natural, rugged terrain that once spanned today’s Upper Midwest.

Included Shore Excursions

La Crosse Hop-On Hop-Off Tour
Dahl Auto Museum Take a stroll down memory lane and immerse yourself in the rich history of the most widely used mode of transportation, the automobile. The Dahl Auto Museum celebrates the Dahl family’s involvement as automotive dealers, with a history spanning over 100 years and five generations. It also features the history of the automobile through the eyes of Ford Motor Company, an extensive mascot collection and many beautifully restored classic automobiles from the turn of the century to present. Suggested Visit: 30 – 45 minutes

Hixon House This beautiful Victorian house is filled with nearly all of the original furnishings, making it stand out from many other historical homes. With 90 percent original furnishings, this nearly hidden downtown gem offers a window into early La Crosse life and the Victorian era around the country.

Premium Shore Excursions

Take to the waters of the Mississippi River on the Winona Tour Boat! Experience the beautiful upper Mississippi River and all it has to offer as our expert captain narrates on the local area and river he calls home. As the boat glides along, Captain Aaron will point out all the local wildlife, including turtles, herons, beavers, deer, ducks, and of course, eagles. Then explore the Winona County History Center, where exhibits showcase an era where the bluffs were just being formed and the area was a booming lumber town. Conclude the day at the Minnesota Marine Art Museum and see collections of original European and American masterpieces. See works by Monet, Picasso, Van Gogh, O’Keeffe, Cassatt, and many more. The museum also features an original “Washington Crossing the Delaware” by German artist, Emanuel Leutze.


Day 9: Red Wing, Minnesota

Red Wing was included on National Geographic Traveler’s list of the world’s most historic places. The port city offers endless opportunities to travel back in time and learn about settlers and pioneers who occupied the land or admire the craftsmanship and creativity of local artisans of both the present and the past.  The first settlers in town built small mills, factories, and workshops, similar to ones they were familiar with in New England where many came from. Immigrants from Germany, Ireland, and Sweden were also skilled craftsman. Some early and persistent industries are tanning and shoe-making. Other businessmen made farm equipment, bricks, barrels, boats, furniture, pottery, and buttons. Consumables included beer and lumber. Service industries including stone-cutting, hospitality, and retailing. The Saint James Hotel remains a working token of the earlier time.

Included Shore Excursions

Red Wing Hop-On Hop-Off Tour
Aliveo Military Museum – The Aliveo Military Museum has a significant collection of military artifacts such as edged weapons, flags, badges and much more! They have a vast collection that includes artifacts and relics from all major wars from the Revolutionary War to the current Middle-East Wars. They believe in education about our military history through preservation, protention and presentation of the military artifacts themselves.

Red Wing Marine Museum – The Red Wing Marine Museum is in one of the city’s historical venues along the river near boathouse village and depicts one of the oldest manufacturing industries-the boat and motor business. It sits very near the site of the original factory where Red Wing-made boats and motors were made and launched. The museum exhibits include more than 30 restored Red Wing orobred marine engines, outboard motors and a display of fishing tackle, photographs, documents and other river-related items.

Premium Shore Excursions

Take to the waters on a scenic kayaking adventure into the vibrant heart of the Upper Mississippi River. Nature will be at your fingertips as you glide by the river’s green banks, beneath the swooping wings of eagles, and atop sky blue waters in your personal kayak. Our expert guide will lead us off the main channel to the river’s backwaters—perfect for guests of all experience levels. Discover the raw, uninhabited beauty of nature along these smooth and shallow waters.


Day 10: Minneapolis (Red Wing) Minnesota

As your American Queen Voyages journey concludes, there are other opportunities for you to take in the town – whether it’s an optional premier post-cruise experience or a quick transfer to the airport for your final trip home – your AQV team can pre-arrange everything for you.


always all-inclusive

Return scheduled flights from London

2-night Pre-cruise Hotel Stay+

Premium City Highlights Tour (Embarkation Day)+


Unlimited Included Guided Tours

Acclaimed Cuisine in Multiple Venues

In-room Dining Available

Unlimited WiFi

Bicycles* and Hiking Sticks

Live, Daily Onboard
Entertainment & Enrichment

Pre-Paid Gratuities

Open Bars & Lounges

Port Taxes & Fees

Unlimited Beverages

*River Cruises Only

+1-night on Minneapolis -New Orleans and Snake & Columbia itineraries/No City Highlights Tour


St Louis to Minneapolis


06, 20 July

03 Aug






16, 30 Aug

27 Sept

sailing aboard

Terms and Conditions

Lead in fares shown are to be used as a guide only, based on the lowest cabin category for two people sharing. Pricing may be subject to change based on flight pricing & availability. Other cabin categories are available. Single cabin grades are available on selected vessels and cabins for sole occupancy are available at a single supplement. All itineraries can be tailor-made to your specification with cruise only, additional hotel nights, flight upgrades and UK regional airport departures (subject to availability).  Additional pre-voyage and post-voyage city stay packages (2 nights) may be purchased for an additional charge. Guests are required to present a credit card upon hotel check-in to cover their incidental charges. In lieu of an included pre-voyage hotel night on any voyage, a $50 per person onboard credit is available upon request and dependent upon voyage date. On a back-to-back voyage, two included hotel nights or a combination of one included hotel night plus a $50 per person onboard credit will be granted in lieu of taking a second included hotel night. All fares, itineraries, hotels, entertainment, shore excursions and other voyage attributes are subject to change, and we are not responsible for errors or omissions therein. American Queen Voyages is represented in the UK & Europe by Light Blue Travel (ABTA D6183 & V9324 ATOL 5489). Full Booking Conditions.


ALERT: View VISA & ESTA requirements update - HEALTH & SAFETY:
This is default text for notification bar
x icon