Louisville to Pittsburgh - 10 Days

Louisville to Pittsburgh Cruise Summary

Cruise the highlights of the Ohio River, beginning with a hotel stay in Louisville, birthplace of the Old Fashioned cocktail and home to the world’s largest baseball bat, the sky-scraping Slugger statue.

Explore the laidback city of Madison on an included Hop-On Hop-Off tour, available here, as it is in each and every port-of-call along the way, including picturesque Cincinnati, known for its legendary chili and bustling waterfront.

Tour the historic Downtown and Old Washington districts of Maysville in Kentucky. Learn more about the mysteries of Point Pleasant, reputedly home to the mythical Mothman. Marietta is another destination that’s alive with frontier history, as is Wheeling in West Virginia, reflecting the prosperity of the industrial era through a range of attractions.

In the Steel City of Pittsburgh, don’t miss the opportunity to experience breathtaking views from the Duquesne Incline funicular railway and tour the Heinz History Centre, as part of our optional post-cruise city tour.



  • Enjoy a pre-cruise hotel stay in one of America’s cultural gems, the hip city of Louisville
  • The frontier history of the Northwest Territory in Maysville, Point Pleasant, Marietta and Wheeling
  • Chance to tour one of America’s most popular travel destinations, Pittsburgh, Pennsylvania



2024 All-inclusive fares from £5,299 pp

louisville to pittsburgh map

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day-by-day itinerary

Day 1: Hotel Stay – Louisville, Kentucky

Arrive in Louisville for your 2-night pre-cruise hotel stay.

Day 2: Hotel Stay – Louisville, Kentucky

Enjoy your time in Louisville at your own leisure. Representatives from American Queen Voyages and our local port/city partner will be available to provide you with dining, entertainment and sightseeing options to maximise your time here.

Day 3: Louisville, Kentucky

This authentically quirky port is a muse to artisans of mixed mediums – from sidewalk chalk to street fare, and home to cultural diversity that quickly captivates the heart of visitors. Named for King Louis XVI of France in appreciation for his assistance during the Revolutionary War, Louisville was founded by George Rogers Clark in 1778. While its initial growth was slow, the advent of the steamboat in the early 1800s sparked booming industrial development, and by 1830 Louisville had secured its place as the largest city in Kentucky.

Included Shore Excursions


Museum Row Louisville’s Museum Row is housed in America’s second largest collection of cast-iron facades. Only New York City’s SoHo district has more 19th century cast-iron storefronts. Located a block south of the Ohio River, Museum Row is home to nearly 10 local attractions in one historic neighborhood. Suggested Visit: 30 minutes – 1.5 hours

The Frazier History Museum With three floors of exhibit space, the Frazier History Museum is a world-class museum that provides an unforgettable journey through more than 1,000 years of history with ever-changing and interactive exhibits, daily performances by costumed interpreters, and engaging special events and programs. The permanent collection features a wide array of historically significant artifacts, such as Teddy Roosevelt’s “Big Stick,” Custer’s pistols, Geronimo’s bow and arrows, and a first edition copy of Uncle Tom’s Cabin. There is much to explore and learn here! Suggested Visit: 1 – 2 hours

Mark Payton Glass Center Visit this glass blowing studio and tour the amazing techniques and artwork created by professionals. The tour will pass by artists in action as they flamework, sculpt, cast, and blow glass. Make sure to stop in the gallery to explore finished products or the gift shop where you can purchase some unique and beautiful souvenirs. Suggested Visit: 15 – 30 minutes

Cathedral of the Assumption Located in the heart of downtown Louisville, this magnificent cathedral was designed in Neo-Gothic style by William Keeley and Isaiah Rogers, two of America’s finest 19th century architects. Completed in 1852, it is the fourth oldest public building in the city of Louisville, as well as the third oldest Catholic Cathedral in the United States in continuous use. The steeple rises 287 feet above the Louisville skyline, and the coronation window is one of the oldest surviving examples of hand-painted stained glass in the country. Suggested Visit: 30 minutes

4th Street Live! Fourth Street Live began as a downtown revitalization project to redesign and modernize the former Louisville Galleria, a similar but unsuccessful project opened in the early 1980s with the same goals of revitalizing downtown. Fourth Street itself had long been the main shopping and entertainment destination in Downtown Louisville. Today, the 350,000-square-foot entertainment and retail complex is located on 4th Street, between Liberty and Muhammad Ali Boulevard, in Downtown Louisville. Restaurants and entertainment venues in the complex include Gordon Biersch Brewing Company, Hard Rock Cafe, T.G.I. Friday’s, Sully’s Irish Pub, The Sports & Social Club (bowling alley and restaurant), tavern on 4th street, The Fudgery, and the first-ever Maker’s Mark Bourbon House & Lounge. Suggested Visit: 30 minutes – 1 hour

Louisville Visitor Center The Louisville Visitor Center is a one-stop-shop for brochures, maps, experience itineraries, dining suggestions, coupons, and shopping for Louisville and Bourbon Country-themed items. Also, attraction tickets are available for purchase and you can pick up and redeem Urban Bourbon and Kentucky Bourbon Trail passports. Find all the information you need for your day in Louisville. Suggested Visit: 15 – 30 minutes

Day 4: Madison, Indiana

Tucked away between Cincinnati and Louisville is Madison, Indiana, a quaint river town rich in character. This charismatic port flaunts its personality throughout the streets, where a 133-block historic district showcases its collection of classic architectural artistry. Admire the antique machinery at the Schroeder House, or an example of fine craftsmanship at the Lanier Mansion State Historic Site. The downtown shopping district is a unique showcase of unbeatable hospitality, with each shop locally owned and operated. Madison’s heritage is woven into every stop, ensuring a glimpse of beauty and history. Madison, Indiana was founded in 1809 along the Ohio River. The city was bursting with commerce, had a very active steamboat port, and was home to Indiana’s first railroad. Due to its unique location and transportation infrastructure, Madison was primed to be a link on the Underground Railroad. The neighbourhood area known as “Georgetown” (which includes the African Methodist Episcopal Church) was designated in 2004 as the only Network to Freedom district. Four of the 11 sites listed for the Indiana Network to Freedom are in the Madison area.

Included Shore Excursions

Madison Hop-on Hop-off Tour – Schroeder Saddletree Factory This factory is America’s very last 19th century saddletree factory. For 94 years, workers at the Ben Schroeder Saddletree Company crafted tens of thousands of wooden frames for saddle makers throughout the United States and Latin America. It was the nation’s longest lasting, continually operated, family-owned saddletree company. After his death, Ben’s family kept his dream alive by adding stirrups, hames for horse collars, clothespins, lawn furniture and even work gloves to their line of saddletrees. The factory closed in 1972 and was left completely intact. Suggested Visit: 30 minutes – 1 hour

Broadway Fountain One of Madison’s landmarks, the original Broadway Fountain stood in the middle of Broadway for almost 100 years before it was dismantled and recast in bronze in 1976. The original Janes, Kirtland, and Company cast iron fountain was displayed at the 1876 Philadelphia Centennial Exposition.

Premium Shore Excursions

Join us on a scenic jet boat ride as we explore 40 miles on two of America’s great rivers. Take a cruise on the Coast Guard approved jet boat for an unforgettable ride on the Ohio River to Carrollton, Kentucky, then ride up the Kentucky River to the historic Lock 1. Soak in the beautiful sights along the way as Captain Paul shares stories of the river, points out historic locations, and helps you spot local wildlife. Enjoy the good laughs, amusing anecdotes, and remember to keep an eye out for bald eagles, osprey, river otters, and more!

Day 5: Cincinnati, Ohio

If there was ever a city built upon a river, it is Cincinnati. First the Ohio River and then the Erie Canal opened this fast-growing trade and transport center, with major manufacturing ports to the south and east. Like most early American settlements, Cincinnati began life as a trading post along the Ohio River. In 1802 it was formed as a village, later becoming a city in 1819. Two major events helped to shape its future – the arrival of steam navigation for boats along the Ohio River and the completion of the Miami and Erie Canal in 1827. The mid-1800s were the boom years and Cincinnati’s population swelled due to easy access via the river and canal network. When the railroad finally made its way to Cincinnati in 1836, the city’s trading prospects expanded even further. The Little Miami Railroad offered new access to Lake Erie’s ports on Sandusky Bay, as well as another major river for navigation. The prosperity that followed allowed Cincinnati to build its first streetcar system and by 1872, the entire city was laid out for public transportation.

Included Shore Excursions

Cincinatti Hop-on Hop-off Tour
Oak Bluffs

This seaside resort from the Victorian era was constructed on historic campgrounds. Today, it features over 300 “gingerbread” cottages and other buildings from the 19th century. The Oak Bluffs is also home to one of the oldest platform carousels, the Flying Horse Carousel.


Enjoy this storybook setting along the waterfront. Gaze upon the elegant Greek revival structures that housed the whaling captains in their heyday. Edgartown is home to many historic structures from the Old Whaling Church to the Harbour Lighthouse.

Premium Shore Excursions

Join us on a journey of biblical proportions as we travel to Kentucky’s Ark Encounter. As you approach, soak in the awe-inspiring full-scale ark replica which stretches across the horizon, offering a remarkable glimpse into the biblical past. Spend the day exploring the modern engineering marvel at your leisure and uncover the detailed story of Noah and the animals residing onboard. The intriguing stories and expansive museum are sure to provide a larger-than-life adventure for any visitor!

Day 6: Maysville, Kentucky

The city of Maysville, Kentucky, boasts a picturesque downtown set on the banks of the Ohio River. Maysville’s heightened passion for diversity of art and live entertainment proves that as long there is a story to be told, it will flourish. Its long-standing romance with opera is on display at the restored 1889 Washington Opera House. Maysville is also home to the Russell Theater, where hometown hero turned Hollywood screen star Rosemary Clooney hosted the red carpet premier for her film “The Stars are Singing” in 1953. Visual arts are celebrated with original exhibits by local artists in Maysville’s galleries.

Included Shore Excursions

Maysville Hop-on Hop-off Tour
Russell Theatre

Constructed in 1929, the Russell Theatre is one of only two atmospheric theatres in Kentucky. The dream of Colonel J. Barbour Russell, a well-known businessman in the wholesale grocery business next door to the theatre, The Russell opened its doors in 1930. Russell’s favorite byline was “What the roxy is to New York, the Russell will be to Maysville.” In 1953, Rosemary Clooney premiered her film, The Stars Are Singing, and today, the lobby is filled with memorabilia that is sure to intrigue any Clooney fans. Admire opulent Spanish Colonial décor that permeates the building from the moment you enter. The Russell has undergone extensive preservation and restoration efforts since 1995, when local townspeople formed The Russell Theatre Corporation (TRTC), saving the historic theatre from demolition with grassroots fundraising. Suggested Visit: 30 minutes – 1 hour

Premium Shore Excursions
Washington, Kentucky from Slavery to Freedom

Day 7: Point Pleasant, West Virginia

Widely recognised for the 1967 collapse of the Silver Bridge, this sleepy river town became a focal point of paranormal enthusiasts in search of Mothman, a creature said to inhabit an abandoned TNT factory from World War II. Visitors can also learn tales of river life, great floods, boat construction, sternwheel steamers, river disasters and the local industry’s contribution to World War II at the Point Pleasant River Museum. A Shawnee village known as Upper Shawneetown was established here before 1749. In the second half of 1749, explorer Pierre Joseph Céloron de Blainville claimed French sovereignty over the Ohio Valley, burying a lead “Point Pleasant” plaque at the meeting point of the Ohio and Kanawha rivers. Céloron’s expedition was a diplomatic failure since local tribes remained pro-British, and British representatives in the region refused to leave. This incident was the prelude to the ultimate expulsion of France from most of its possessions in North America.

Included Shore Excursions

Point Pleasant Hop-on Hop-off Tour
Tu-Endie-Wei State Park Located on 4 acres at the confluence of the Ohio and Kanawha Rivers, Tu-Endie-Wei State Park means “point between two rivers” in the Wyandotte language. Inside the park is an 84-foot granite monument that commemorates the frontiersmen who lost their lives in the 1774 Battle of Point Pleasant. This battle was fought with Chief Cornstalk on October 10,1774, and is recognized as the decisive engagement in a proactive series of Indian wars. The park also features the Mansion House Museum, which is the oldest and largest log cabin in the Kanawha Valley. Built in 1796, it was used as a tavern for many weary frontiersmen, including Daniel Boone and Simon Kenton. Suggested Visit: 15 – 30 minutes

Day 8: Marietta, Ohio

Known as the “Riverboat Town,” Marietta is located at the confluence of the Ohio and Muskingum rivers and is the oldest city in the state of Ohio. Because of its location along the river, Marietta grew quickly becoming a major trading centre in the Northwest Territory. In 1811, as steamboats began to churn in America’s rivers, Washington County entered a boom era, bolstered by settlers passing through, ship-building, and commerce. Since then, many historical sites have been beautifully preserved within Marietta and Washington County, reminding all residents and visitors that America’s westward expansion began in this small but mighty, riverboat town.

Included Shore Excursions

Marietta Hop-on Hop-off Tour
Mound Cemetery Established in 1801, Mound Cemetery is one of the oldest cemeteries of the original Northwest Territory. The cemetery holds founders and settlers of Marietta and veterans of almost every American war are also buried here. Mound Cemetery is home to the largest number of Revolutionary War officers buried in a single location. In the middle of the cemetery, the earthwork structure known as Conus Mound prominently stands 30 feet high. Conus is thought to be an actual burial mound, probably containing the remains of hundreds of Native Americans. Visitors can take the steps to the top, where there are benches to sit and admire the view. Suggested Visit: 15 – 30 minutes

Premium Shore Excursions
The Wilds – A Safari Experience

Day 9: Wheeling, West Virgina

By the early 1880s, trade along the Ohio River made Wheeling a popular frontier town. After National Road – the nation’s first roadway – was created by an Act of Congress, Wheeling became known as the “gateway to the west.” Wheeling was established as a town in 1795 and incorporated in 1836 through a charter granted by the Virginia Assembly. Wheeling was loyal to the Federal Government during the Civil War and the State of West Virginia was born here. It was welcomed into the Union as a state on June 20, 1863. Wheeling was the capital of the newly formed state from 1863 to 1870 when it was moved to Charleston. Through an active industrial economy and large working population, Wheeling became the richest city per capita in America at the end of the 19th century. Iron and steel mills developed on the banks of the Ohio River. Other industries, including glass works and cigar factories, also flourished here. The manufacture of cut iron nails took off and soon Wheeling was known as the “nail capital of the world.”

Included Shore Excursions

Wheeling Hop-on Hop-off Tour

Wheeling Artisan Center A stunning historic preservation project, the Wheeling Artisan Center is a renovated 1860s industrial building in the heart of downtown. With construction dating to before the Civil War, two adjacent foundry plaques at the base of the pilasters clearly illustrate the statehood of West Virginia. One is marked “VA.” while the other is inscribed “W.VA.” The three-story atrium welcomes guests inside, where there is a restaurant, regional artisan shop, “Made in Wheeling” exhibits, an event space, and the Wheeling Heritage headquarters. Suggested Visit: 30 minutes

Centre Market/Shopping Built in 1853, the Centre Wheeling Market is a historic public market located along Market Street between 22nd and 23rd Streets. The market is older than the state itself. The Upper Market House is the eldest market house in the country. Local business owners in and around the Centre Market square strive to bring back the comfort of home. The Centre Market has a wide arrange of shops and restaurants, including hand-crafted jewellery and pottery and a fish market. There is something here for everyone!
Suggested Visit: 15 – 30 minutes

West Virginia Independence Hall Nearly six years before President Lincoln signed the proclamation making West Virginia the 35th State in the Union, construction had begun on the Wheeling Custom House, headquarters for federal officers for the Western District of Virginia. Its completion, coinciding with the Civil War, provided a facility for political discussions and constitutional conventions. The grand architecture of the building’s interiors have been restored to be authentic to the time period in which it portrays. Guests can view an interpretive video and take a self-guided tour of the building.
Suggested Visit: 30 minutes

Eckhart House Built in 1892 by wealthy banker George W. Eckhart Jr., the Eckhart House was considered to be one of the residential building achievements of the year by the Wheeling Daily Intelligencer in October 29, 1892. With most of its original architectural features well preserved, it has earned the title of Victorian Wheeling’s ‘Crown Jewel’. The three-story Queen Anne townhome is nestled in the heart of Victorian Old Town and is listed on the National Register of Historic Places. Besides tours, the Eckhart House has a tea room and a gift shop.
Suggested Visit: 15 – 30 minutes

Capitol Theatre The Capitol Theatre is the largest theatre in West Virginia and a landmark building in the national historic district of downtown Wheeling. For many years, it has served as the home of Jamboree USA and the Wheeling Symphony Orchestra. The Capitol Theatre opened its doors for the first time on November 29th, 1928 for four different shows with each seat costing sixty cents. The building originally had a copper marquee with a large and electric neon sign at the entrance and was composed with a color scheme of mulberry, delicate green tones, ivory, and various shades of gold russet. Suggested Visit: 15 – 30 minutes

Premium Shore Excursions

Wheeling, West Virginia is nestled cozily along the banks of the Ohio River and offers century-spanning historical sites. Wheeling was established as a town in 1795 and incorporated in 1836 through a charter granted by the Virginia Assembly. It was loyal to the Federal Government during the Civil War and the State of West Virginia was born here. Through an active industrial economy and large working population, Wheeling became the richest city per capita in America at the end of the 19th century. This is evident in the city’s grand architecture of the beautiful mansions which stand today as a testimony to the earlier time of wealth.


Day 10: Pittsburgh, Pennsylvania

As your American Queen Voyages journey concludes, there are other opportunities for you to take in the town — whether it’s an optional premier post-cruise experience or a quick transfer to the airport for your final trip home — your AQV team can pre-arrange everything for you.


always all-inclusive

Return scheduled flights from London

2-night Pre-cruise Hotel Stay+

Premium City Highlights Tour (Embarkation Day)+


Unlimited Included Guided Tours

Acclaimed Cuisine in Multiple Venues

In-room Dining Available

Unlimited WiFi

Bicycles* and Hiking Sticks

Live, Daily Onboard
Entertainment & Enrichment

Pre-Paid Gratuities

Open Bars & Lounges

Port Taxes & Fees

Unlimited Beverages

*River Cruises Only

+1-night on Minneapolis -New Orleans and Snake & Columbia itineraries/No City Highlights Tour


louisville to pittsburgh


14, 28 June






07 June




sailing aboard

Terms and Conditions

Lead in fares shown are to be used as a guide only, based on the lowest cabin category for two people sharing. Pricing may be subject to change based on flight pricing & availability. Other cabin categories are available. Single cabin grades are available on selected vessels and cabins for sole occupancy are available at a single supplement. All itineraries can be tailor-made to your specification with cruise only, additional hotel nights, flight upgrades and UK regional airport departures (subject to availability).  Additional pre-voyage and post-voyage city stay packages (2 nights) may be purchased for an additional charge. Guests are required to present a credit card upon hotel check-in to cover their incidental charges. In lieu of an included pre-voyage hotel night on any voyage, a $50 per person onboard credit is available upon request and dependent upon voyage date. On a back-to-back voyage, two included hotel nights or a combination of one included hotel night plus a $50 per person onboard credit will be granted in lieu of taking a second included hotel night. All fares, itineraries, hotels, entertainment, shore excursions and other voyage attributes are subject to change, and we are not responsible for errors or omissions therein. American Queen Voyages is represented in the UK & Europe by Light Blue Travel (ABTA D6183 & V9324 ATOL 5489). Full Booking Conditions.


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